Preventive role of platelet rich plasma (PRP) in experimentally induced osteoarthritis in rabbit’s knee joint

AshEse Journal of Medicine and Medical Researches                                                                  

Vol. 1(4), pp. 016-022, August, 2015 

ISSN: 2059-1233

© 2015 AshEse Visionary Limited  

 

Full Length Research

Kalbkhani M.1*, Dehghani S. N.2, Naji Haddadi S.3, Najafpour A. R.1, Ghorbanzadeh N.2 and Kalbkhani M. H.4

1Young researchers and Elite Club, Urmia branch, Islamic Azad University, Urmia, Iran.

2Department of Veterinary Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

3Department of Pathology, Urmia University of Medical Sciences, Faculty of Medicine, Motahari hospital, Urmia, Iran.

4Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran.

*Corresponding author: E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..

Received July, 2015; Accepted July, 2015

Osteoarthritis (OA) is the most common type of arthritis and the major cause of chronic musculoskeletal mobility disability in the elderly populations worldwide. In this study, scaffold free autogenous platelet rich plasma (PRP) was used in an experimental animal model of OA by direct intra articular injection. 15 white New Zealand adult rabbits of both sexes were used in this study. OA was induced by anterior cruciate ligament transection of the knee joints. Immediately following operation, a single dose of (0.5 ml) platelet rich plasma (PRP) was delivered to the injured knee by direct intra articular injection in the test groups. The control group received no PRP injection. The knees were examined after four and eightweeks following the operation histopathologically. Pathologic assessment confirmed development of OA changes after8 weeks in the control group. Rabbits which received PRP showed lower degree of cartilage degeneration, osteophyte formation, and subchondral sclerosis than the control group at 8 weeks after surgery. In conclusion, PRP could be a valuable medium and a promising source for the prevention of the development of OA.

Key words: Prevention of osteoarthritis, platelet rich plasma, histopathologic assessment, stifle joint.

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