AshEse Journal of Medicine and Medical Researches
Vol. 1(2), pp. 005-008, March, 2015
© 2015 AshEse Visionary Limited
Full Length Research
Nandin, G.1*, Shine-Od, D.1, Aldarmaa, T.1, Avirmed, A.1, Bayarmaa, E.2, Enebish, S.1, Munkhzol, M.2, Uranchimeg, D.1 and Amgalanbaatar, D.1
1Department of Morphology, MNUMS, Mongolia.
2Department of Pathophysiology and Pathoanatomy, MNUMS, Mongolia.
Received 25 February, 2015; Accepted 23 March, 2015
Although Mongolian people use as much animal fat and salt in the food, the level of cholesterol was determined relative as normal. But recently, their life style changed by the influence of social factors and non-infections disease quite increased, including atherosclerosis. For this reason, we aimed to study the wall structure of coronary artery and to determine some biomarkers in the relatively healthy persons and coronary atherosclerotic patients’ autopsy. Twelve autopsies from 21 to 74 aged cadavers were included in this study. All specimens were processed with Haematoxylin-Eozin stained andthe changes of coronary arterial wall structure were examined by the special staining with Van-Gizon, three chrome Masson: the atherosclerotic plaques, neovascularization and fat crystals were observed in the wall of the coronary artery with atherosclerosis. By the immunohistochimical staining, the presence of vascular cell adhesion molecule (VCAM-1) was detected in the endothelial cell membrane, vascular endothelial growth factor (VEGF) was slightly immunoreacted in the nucleus, cytoplasm and of endothelial cell membrane, but PECAM-1 and LOX-1 were not detected in the wall of injured coronary artery, suggesting a role of VCAM-1 in atherosclerosis.
Key words: Atherosclerosis, vascular cell adhesion molecule (VCAM), intracellular adhesion molecules (ICAM), vascular endothelial growth factor (VEGF)