The identification of some biomarkers of coronary arteriosclerosis

AshEse Journal of Medicine and Medical Researches

Vol. 1(2), pp. 005-008, March, 2015

ISSN: 2059-1233

© 2015 AshEse Visionary Limited 

 

Full Length Research

Nandin, G.1*, Shine-Od, D.1, Aldarmaa, T.1, Avirmed, A.1, Bayarmaa, E.2, Enebish, S.1, Munkhzol, M.2, Uranchimeg, D.1 and Amgalanbaatar, D.1

1Department of Morphology, MNUMS, Mongolia.

2Department of Pathophysiology and Pathoanatomy, MNUMS, Mongolia.

*Corresponding author. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Received 25 February, 2015; Accepted 23 March, 2015

 

Although Mongolian people use as much animal fat and salt in the food, the level of cholesterol was determined relative as normal. But recently, their life style changed by the influence of social factors and non-infections disease quite increased, including atherosclerosis. For this reason, we aimed to study the wall structure of coronary artery and to determine some biomarkers in the relatively healthy persons and coronary atherosclerotic patients’ autopsy.  Twelve autopsies from 21 to 74 aged cadavers were included in this study. All specimens were processed with Haematoxylin-Eozin stained andthe changes of coronary arterial wall structure were examined by the special staining with Van-Gizon, three chrome Masson: the atherosclerotic plaques, neovascularization and fat crystals were observed in the wall of the coronary artery with atherosclerosis. By the immunohistochimical staining, the presence of vascular cell adhesion molecule (VCAM-1) was detected in the endothelial cell membrane, vascular endothelial growth factor (VEGF) was slightly immunoreacted in the nucleus, cytoplasm and of endothelial cell membrane, but PECAM-1 and LOX-1 were not detected in the wall of injured coronary artery, suggesting a role of VCAM-1 in atherosclerosis.

 

Key words: Atherosclerosis, vascular cell adhesion molecule (VCAM), intracellular adhesion molecules (ICAM), vascular endothelial growth factor (VEGF)

Read Full Article

 

Latest Journals

  • Critical Analysis for Approaches of Estimating Tax Revenue Potential and Effort +

    AshEse Journal of Economics                                                                 Vol. 6(5), pp. 307-309, November, 2020 ISSN: 2396-8966   © 2020 AshEse Visionary Limited  Book Chapter   Critical Read More
  • Biological Control of Erwinia Amylovora in Apple Trees Employing Antibacterial Agents +

    AshEse Journal of Agricultural Science                                                                   Vol. 3(4), pp. 117-126, November, 2020 ISSN: 2059-1225   © 2020 AshEse Visionary Limited    Full Length Read More
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
  • 11
  • 12
  • 13
  • 14
  • 15
  • 16
  • 17
  • 18
  • 19
  • 20
  • 21
  • 22
  • 23
  • 24
  • 25
  • 26
  • 27
  • 28
  • 29
  • 30
  • 31
  • 32
  • 33
  • 34
  • 35
  • 36
  • 37
  • 38
  • 39
  • 40
  • 41
  • 42
  • 43
  • 44
  • 45
  • 46
  • 47